Abstract: A refractory lead-bearing silver ore from Henan is characterized by high oxidation rate,high mud content,and belongs to lead-bearing silver ore with poor sulfide content.In production,the silver loss rate of tailings is high.Based on the ore property,experimental study on run-of-mill ore gravity separation-gravity separation tailings flotation was carried out and the beneficiation performance under different grinding fineness and reagent regime was investigated.The results show that when the dosage of Na2CO3 is 300 g/t,Na2S is 200 g/t and other parameters are optimal for the closed-circuit flowsheet of run-of-mill ore gravity separation-gravity separation tailings flotation,the gravity concentrate with silver grade of 8 892.40 g/t,lead grade of 18.35 % can be obtained,as well as the flotation concentrate with silver grade of 8 855.50 g/t,lead grade of 17.87 %,and copper grade of 1.560 %;the total recovery rates of silver,lead and copper are 81.31 %,71.92 %and 73.12 %respectively.Each metal gets well concentrated and recovered.