Abstract: The molybdenum oxidation rate of a large-scale tungsten-molybdenum mine reaches 42.45 %.The intimate association of molybdenum,tungsten,iron,and fluorite minerals,with fine particle size,and high content of calcium-magnesium silicates,carbonates,and clay minerals,distributed extremely uneven,poses challenges in ore-dressing.To address this complexity in processing polymetallic ores,an industrializable and relatively simple crushing and grinding-magnetic separation-desliming-flotation process was adopted.This process yielded molybdenum sulfide concentrate (containing 45.76 % molybdenum),molybdenum oxide-tungsten oxide concentrate (containing 15.88 % molybdenum and 22.65 % tungsten),and iron concentrate (containing 63.11 % iron).The recovery rates of molybdenum,tungsten,and iron were 67.75 %,51.84 %,and 36.44 % respectively,achieving effective resource recovery.Pre-desliming before flotation facilitates smooth flotation operations,reduces reagent consumption,and stabilizes the recovery of valuable minerals.