Abstract: In light of high consumption of spiral lining plate and increased consumption of sodium cyanide and zinc due to the adoption of high chromium steel balls used as grinding media of vertical mills,Jinchiling Gold Mine carried out experimental study on the replacement of high chromium steel balls by nano-ceramic balls and their industrial application.The results show that the optimal operation conditions were as follows:grinding concentration (66±2)%,operation current (13±2)A,ball supplementation system and the mass ratio of φ25 mm and φ20 mm was 2∶1.Compared with high chromium steel balls,nano-ceramic balls have the same particle size distribution,grinding efficiency and gold leaching rate,while the iron pollution is reduced,the ball consumption is reduced from 7.720 yuan/t to 0.191 yuan/t,and the spiral lining plate consumption is reduced from 3 sets per year to 1.69 sets per year.2 491 500 yuan can be saved for the total annual cost,and good economic results are achieved.