Abstract: In the new era, the mining industry is confronted with multiple challenges including resource security, ecological safety, and occupational health, which urgently requires the exploration of transformation pathways. This paper systematically analyzed the potential impacts of mining activities on the ecological environment and human life safety and identified the shortcomings of the current model in aspects such as background surveys of harmful elements, safety risk prevention and control, treatment of "three wastes" （waste gas, waste water, and waste residue）, and community health. The research proposes that promoting the transformation of mining towards greening and ecologicalization is the fundamental solution. It advocates extending the connotation of green mine construction to the sustainable utilization after mine closure and realizing ecological restoration and industrial continuation through the development of models such as "agricultural mines", thereby opening up the transformation channel from "lucid waters and lush mountains" to "invaluable assets". Furthermore, this paper discussed the medicinal value of mineral resources, the potential health correlations and cultural origins of meteorites, as well as the health-preserving functions of geothermal resources, aiming to broaden new horizons for mineral resources to serve human health. Recommendations are put forward, including strengthening interdisciplinary research, improving policies and standards, and promoting international cooperation, so as to drive the coordinated development of mining and ecological safety and contribute to the construction of a "healthy China" and a "beautiful China".