Abstract: The main valuable elements that can be comprehensively recovered from a sulfide lead-gold ore in Jilin Province are mainly lead,gold and silver.Experimental study of preferential flotation was conducted based on the peculiar property of the ore and identified the optimal value of special parameters such as grinding fineness,reagent regime.The results show that under optimal conditions,the preferential flotation process of lead flotation prior to gold can obtain the lead concentrate with lead grade 40.86 %,lead recovery rate 90.03 %,gold grade 54.05 g/t,gold recovery rate 27.91 %;the gold concentrate with lead grade 0.65 %,lead recovery rate 5.90 %,gold grade 28.30 g/t,gold recovery rate 60.17 %.The test results bear guiding significance to efficient recovery of lead and gold from the sulfide lead-gold ore and its industrial production.