Abstract: In view of the characteristics of cyanide residue in a gold enterprise,a variety of detoxification treatment experiments such as solid-liquid separation washing method,hydrogen peroxide oxidation method and ozone oxidation method were carried out,aiming to meet the requirements of backfill HJ 943—2018 Technical Specification for Pollution Control of Cyanide Leaching Residue in Gold Industry.At the same time,an exploratory backfill test was carried out on the treated cyanide residue,and related parameters such as properties and filling strength were investigated to provide basis for further industrial design in the future.The experimental research shows that the solid-liquid separation washing method+ozone oxidation method can achieve the expected target of the cyanide residue treatment.After detoxification,the cyanide residue is a relatively qualified underground backfill material.However,the cyanide residue filling since body under experimental conditions has relatively poor uniaxial compressive strength,more ideal binding materials are yet to be found in the future and reasonable design of the filling body needs to be made to meet the mine production demand.