Abstract: On a comprehensive basis of the characteristics of geological,geophysical and geochemical anomalies,the 1∶50 000 stream sediment survey in Wuergou area was carried out,finding that the ore-bearing strata in Wuergou area are the Kawabulake Rock Group of Jixian System and the Tianger Formation of Upper Devonian; the ore-controlling structure is Bingdaban ductile shear zone; the alteration of surrounding rock is mainly silicification,jarosite,potassification,peacock petrification and serpentine while the mineralization is mainly scheelite and carbonization;the prospecting target area (B-2) of Modetu Au-Cu-graphite and the prospecting target area (A-1) of Guoguang North tungsten-molybdenum are determined,and the geological-geophysicical-geochemical comprehensive prospecting model is constructed,providing a new idea and direction for next-step ore prospecting work.