Abstract: The hydrogen,oxygen,sulfur,and lead isotopes of Yinshan copper-lead-zinc polymetallic deposit were studied to determine the sources of ore-forming materials.The research results indicate that the δD values range from -78.9 ‰ to -28.5 ‰,with an average value of -56.5 ‰;the δ18OV-SMOW values range from 12.10 ‰ to 18.70 ‰,with an average value of 16.06 ‰;the δ18OH2O values range from 0.18 ‰ to 11.26 ‰,with an average of 8.24 ‰,indicating a mixture of magmatic water and atmospheric precipitation as the ore-forming fluids.The δ34S values range from -1.04 ‰ to 2.71 ‰,with an average value of 1.35 ‰,which is significantly different from the sulfur isotopes of the ore-bearing strata of Zhangcun Formation in the mining area,suggesting that the ore-forming materials do not directly come from the strata but have a clear mantle sulfur (-3 ‰ to 3 ‰) signature,closely related to volcanic-subvolcanic activities in the mining area.The lead isotopes (206Pb/204Pb = 17.890 0-18.319 0,207Pb/204Pb=15.528 0-15.602 5,208Pb/204Pb=38.025 2-38.445 0) indicate a mixed source of crust and mantle,and the ores have an affinity with the magmatic rocks.