Abstract: The research subject is a microfine-particle disseminated refractory sulfide gold ore from Ili,Xinjiang,and the grade of Au in the ore is 3.69 g/t.In addition to a large amount of quartz and silicate minerals,the ore contains lots of alumina and calcium magnesium minerals,and is also seriously argillaceous.According to the properties of the ore,with the optimization of regulators and collectors,the reasonable regime of agent was established.The final closed-circuit test obtained good technical index: the gold grade in the gold concentrates was 45.16 g/t and the recovery rate was 84.20 %.