Abstract: The Kangdenongshe Gold Polymetallic Deposit is a newly discovered deposit in the east section of east Kunlun metallogenic belt.Based on the study of geological setting and geological characteristics of deposit,it can be divided into 3 mineralization periods,and hydrothermal phase can be further divided into 4 mineralization stages,and sphalerite-galena-quartz-chalcopyrite stage and barite-sulfide stage are main metallogenic stages.The result of fluid inclusion analysis indicates that fluid inclusions of gold polymetallic ore and lead-zinc ore have the characteristics of low temperature,low density and medium low salinity.The ore-forming fluids primarily derive from magmatic water and partly from meteoric water.The result of stable isotopic test shows that ore-forming material sources are mainly mantle-derived magmatic hydrothermal fluids mixed with marine sulfate.The determination of ore-forming fluids and ore-forming material source of Kangdenongshe Gold Polymetallic Deposit can provide reference for exploration of similar deposits in east Kunlun metallogenic belt.