Abstract: The Kaliguoma W-Mo Deposit is located on the contact zone of North Qilian metallogenic belt and Middle Qilian metallogenic belt,where the ore-forming geological condition is superior.The ore bodies in this area mainly occur in the mineralized alteration zone that is the outer contact zone of the Lower Proterozoic Tuolaiyan Group biotite adamellite and dimica adamellite,where hydrothermal fluid type scheelite and molybdenite,quartz vein type and fluorite type shceelite formed.The stronger the silicification and fluoritization are,the higher the tungsten mineralization is,suggesting silicification and fluoritization are important prospecting indicators.1∶10 000 soil geochemical survey is conducted in 1∶200 000 stream sediment AS16乙2 Daheishan W and Mo anomalies and 1∶50 000 stream sediment AS05 comprehensive anomalies,delineating 6 soil comprehensive anomalies(AP1-AP6).Each soil comprehensive anomaly is characterized by high intensity and large area.Each anomalous element has good sets and high maximum value and most of them are characterized by inner,middle and outer three-level anomaly zonation and distinct concentration center.Comprehensive analysis shows that Kaliguoma W-Mo district has superior ore-forming conditions,and develops geochemical anomalies.Prospecting signs have been found as well as certain amounts of resources,fully showing the prospecting potentials in the area.It is expected that further prospecting work can yield good prospecting achievements.