Abstract: According to the characteristics of a certain gold production enterprise in Guizhou and the practical production requirements of the enterprise,pressurized hydrolysis is used for comprehensive treatment of cyanide tailings and the test conditions are optimized.The results showed that the optimal parameters were:reaction pressure 1.0 MPa,initial temperature 170 ℃ and reaction time 2.0 h,and that pH value of cyanide tailings had no effect on the treatment effect.Under optimal test conditions,the removal rate of total cyanide compound is over 99.9 %,total cyanide compound in the treated residue toxic leach solution(water content about 45 %) meets tailings reservoir treatment requirement of HJ 943—2018 "Code for Cyanide Residue Pollution Control of Gold Industry",and the treated recycled water has no adverse effect on beneficiation index.