Abstract: A flotation process was developed that prioritizes lead selection followed by zinc selection,taking into account the diverse ore types and complex symbiotic relationships.In the lead flotation process,the new collector HB-600 as a replacement for some Sodium diethyldithiocarbamate was introduced and the separation process of once roughing-twice scavenging-three times cleaning was used;while in the flotation of lead and zinc,the new collector HB-369,the separation process of once roughing-three times scavenging-three times cleaning was used.Field industrial commissioning results show that the processes can obtain a lead concentrate with a grade of 57.21 % and a recovery rate of 94.48 %,as well as a silver grade of 1 688.3 g/t and a silver recovery rate of 88.52 %;a zinc concentrate with a grade of 48.07 % and a recovery rate of 88.25 %.These results provide valuable references for optimizing the mineral processing technology of lead-zinc-silver polymetallic ores.