Abstract: Experimental research was carried out on the gold extraction from a refractory gold-silver ores containing water soluble nantokite and the ways in which copper minerals dissolve in washing and copper is leached in cyanidation systems were investigated.The results show that the ores treated by pretreatment-flotation-cyanidation can have good index; after the ore samples are washed to remove copper,carbon flotation reagent and new type composite collector are used for flotation,which can effectively reduce the gold grade in tailings; flotation concentrates are grinded with cyanidation barren solution while NaOH are added to adjust pH＞10,by which the NaCN consumption can be greatly reduced,from 110 mL,for direct cyanidation,to 70 mL,and Au leaching rate can reach 94.8 % and Ag leaching rate 91.0 %.