Abstract: The particle size of gold minerals in a microfine disseminated gold ore with low sulfide content is fine,with -0.010 mm microfine-particle gold accounting for 81.16 %,and the gold minerals are mainly encased gold and intergranular gold.Based on the ore property,the experimental comparative research on run-of-mill ore all-sliming cyanidation and flotation was carried out.The results show that the gold recovery performance is not so good when run-of-mill ore all-sliming cyanidation is applied; when the flotation process is applied,and with proper flotation parameters,the flow of once roughing,three times cleaning,three times scavenging,and middling regrinding gets the gold concentrate of the gold grade of 27.64 g/t and the gold recovery rate of 88.88 %;the flotation process with middling regrinding is the suitable ore-dressing process for the ore.