Abstract: Lameizhasha area of Gansu Province is located in the middle Qinling gold-copper-lead-zinc polymetallic ore belt north Xiahe-Hezuo fault and with complex geological structure and favorable ore-forming conditions. Based on 1：50000 stream sediment survey， 1：10000 soil survey， 1：10000 geological sketch survey and preliminary survey of soil comprehensive anomaly， ore (mineralized) bodies are found. The ore (mineralized) bodies are evidently controlled by Meiwu rock mass and wallrock contact zone， fault， and closely related to tourmalinization， silicification， malachitization， pyritization， hermitization and limonitization； Au， Cu， Ag， As， Sb element anomaly curve peak can indicate the existence of ore (mineralized) body； the magnetic susceptibility of ore (mineralized) body is generally below 10×10^-5SI(κ)， displaying weak-zero magnetic characteristics. Geological， geophysical and geochemical profiling is set on favorable ore-forming spots， and based on prospecting indicators， prospecting model of the study area is established， which is verified by the delineation of 2 lead-copper ore (mineralized) bodies and 1 gold-copper ore (mineralized) body.